Fighting fat with… fat?

What do explosives and weight loss have in common?* To find out we need to go back to World War One, to a munitions factory in France. People working with explosives were running high temperatures and losing weight. Some dangerously so. This was no fever, due to some viral or bacterial infection. It was due to a chemical they were using, similar in structure to TNT: dinitrophenol (DNP). Later, in the 1930s, DNP popped up again, this time marketed as a treatment for obesity. It failed due to its high toxicity. We now know how DNP causes these bizarre effects; it short-circuits a key process used by cells to store energy in chemical form, releasing it as heat instead. We’ve since discovered that this is a trick mammals are born to do to. A type of fat, called ‘brown adipose tissue’, or BAT, does the same trick as DNP, only ...(Read More)