Finding the un-natural in the lab…

Taming the power of the immune system in the lab wasn’t easy. For a start, it was a mystery how we have so many different antibodies, millions at any one time. But if it’s one gene per protein, and we only had something like 30,000 genes, how could we have millions of different antibodies? Understanding this problem was the key that unlocked one way to make antibodies against targets that we select. We can use them as tools in the lab, or to treat disease—therapeutic antibodies. Chances are you may know someone who has, or is, using them; if they have Crohn’s disease for example. Just finding antibodies that stick to a target—some unique bump, crevice or corner on a virus, for example—isn’t enough. The next step is to find out if they do something useful. They may stick but not prevent infection, or not activate some receptor on a ...(Read More)